Are Your Thyroid and Depression Symptoms Related? It’s undeniable: Our mental health and our physical health are deeply intertwined. Everything from vitamin deficiencies to lack of physical activity can send our brains down the path of depression, anxiety and mood swings, and it can keep us in a perpetual cycle of depression. When you don’t take care of your body, you become depressed, and when you become depressed, you’re less likely to focus on your health. But it helps if you understand the many reasons why you might be depressed so that you can pull yourself from the never-ending rotation for good. Yes, Thyroid and Depression Go Hand-in-Hand One of the most surprising causes of depression is thyroid disease , a condition where the thyroid doesn’t produce enough hormones. This disease, commonly known as hypothyroidism, causes a wide range of physical and mental side effects, including weight gain, fatigue, achiness, thinning hair, impaired memory, puffy face, dry skin, muscle weak